Therapeutic efficacy of Xiaojianzhong decoction combined with massage therapy in the treatment of anorexia in children with spleen and stomach deficiency-cold syndrome and its effect on serum leptin, gastrin and trace elements in children

QIAO Xiaoyang; ZHANG Yuan; FU Qian; SU Xiaoxia

doi:10.3969/j.issn.1671-038X.2025.05.10

Article navigation > Chin J Integr Tradit West Med Dig > 2025 > 33(5): 527-532

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QIAO Xiaoyang, ZHANG Yuan, FU Qian, et al. Therapeutic efficacy of Xiaojianzhong decoction combined with massage therapy in the treatment of anorexia in children with spleen and stomach deficiency-cold syndrome and its effect on serum leptin, gastrin and trace elements in children[J]. Chin J Integr Tradit West Med Dig, 2025, 33(5): 527-532. doi: 10.3969/j.issn.1671-038X.2025.05.10

Citation:

Therapeutic efficacy of Xiaojianzhong decoction combined with massage therapy in the treatment of anorexia in children with spleen and stomach deficiency-cold syndrome and its effect on serum leptin, gastrin and trace elements in children

Department of Pediatric, Shijiazhuang Traditional Chinese Medicine Hospital, Shijiazhuang, 050051, China

More Information

Corresponding author: SU Xiaoxia, E-mail: zyyek8667@163.com

Received Date: 17 September 2024

Publish Date: 15 May 2025

Abstract

Abstract

Objective
To evaluate the clinical efficacy of Xiaojianzhong decoction combined with massage therapy in treating pediatric anorexia nervosa associated with spleen and stomach deficiency-cold syndrome, and to assess its effects on serum leptin, gastrin, and trace element levels.
Methods
A total of 200 children diagnosed with anorexia nervosa at Shijiazhuang Traditional Chinese Medicine Hospital between June 2021 and December 2023 were randomly assigned into the control group and the observation group (100 cases each) using a random number table method. The control group received standard symptomatic treatment based on western medical guidelines, including gastrointestinal motility enhancement, digestive enzyme supplementation, and trace element replacement. The observation group received Xiaojianzhong decoction and massage therapy in addition to the control group's regimen. Key outcome measures included time to appetite recovery, weight gain, serum levels of leptin, gastrin, and trace elements, traditional Chinese medicine (TCM) symptom scores, overall treatment efficacy, and incidence of adverse reactions.
Results
The total effective treatment rate in the observation group was 96%, significantly higher than the 89% observed in the control group (P < 0.05). Post-treatment levels of serum leptin, gastrin, and trace elements improved in both groups, with greater improvements seen in the observation group (P < 0.05). Additionally, the observation group exhibited a shorter time to appetite recovery, greater weight gain, and lower TCM symptom scores compared to the control group (P < 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).
Conclusion
Xiaojianzhong decoction combined with massage therapy appears to be a safe and effective treatment for anorexia nervosa in children with spleen and stomach deficiency-cold syndrome. This integrated approach not only alleviates clinical symptoms and improves gastrointestinal function but also enhances nutritional biomarkers, warranting its broader application in clinical practice.
- children anorexia /
- spleen and stomach deficiency-cold syndrome /
- Xiaojianzhong decoction /
- massage therapy /
- leptin /
- gastrin /
- trace elements

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References

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